The article describes performance and stabilization factors in the context of macroeconomic performance of small and medium-sized enterprises (SMEs), which comprise also family businesses (SMEs) in the Czech Republic. We consider the number of SMEs active entrepreneurial subjects, the number of SMEs employees, the accounting value added of SMEs and the wage costs of SMEs the performance and stabilization factors. As a representative of macroeconomic performance the authors chose GDP. The stability and performance of SMEs are examined through statistical methods: the Pearson correlation coefficient and the average growth factor. The statistical methods are applied to the data time series between 2002 and 2016. The stability and performance factors are mutually measured and evaluated.