The article deals with the destruction of trichological material due to commonly available substances such as acids and hydroxides. The theoretical part is supplemented by an experiment to determine the possibility of degradation of trichological material. Commonly available substances were used for the experiment, and those were selected for which the effect on the hair fiber was expected. The influence of gender is especially visible, male hair is more resistant to decomposition than female hair. Hair treated with bleaching and dyeing is generally more susceptible to chemicals. In uncoloured hair, blond hair is more susceptible to chemicals. The effect of age was observable in the experiment with Sav. Hair from the oldest donors was much more susceptible and dissolved faster in Sava, even though it was not among the damaged hair due to cosmetic treatments. The effect of drugs is not negligible, however, we did not take into account the types of drugs in the experimental part.