The article deals with the issue of drug crime in the air transport environment, focusing on an empirical analysis of the seizure of narcotics and psychotropic substances at Václav Havel Airport in Prague in 2021–2025. The text is based on real data from criminal files of the Customs Administration of the Czech Republic and combines quantitative statistical analysis with qualitative analysis of selected case studies. Attention is paid to the development of trends in connection with the Covid-19 pandemic, changes in the methods of smuggling used and the adaptability of offenders to control mechanisms. The article identifies the basic typology of drug smuggling methods in air transport and emphasizes the importance of criminalistic tactics, behavioral assessment of persons and the use of technical detection means. The conclusions of the work have application significance for criminalistic practice, prevention and optimization of control procedures in the aviation environment.